Haijun Xiao

Ph.D. in Material Science and Engineering, Tomas Bata University

Dissertation: Drug Self-Delivery Systems for Enhanced Targeted Cancer Therapy.
Coursework: Biommaterials, Pharmaceutics, Pharmaceutical Analysis.

M.S. in Chinese Medicinal Science, University of Macau

Dissertation: Effects of X-shaped Reduction-sensitive Copolymer on Drug Delivery.
Coursework: Molecular Pharmaceutics, Targeted Drug Delivery, Biosafety Evaluation.

B.S. in Pharmaceutics, China Pharmaceutical University

Coursework: Pharmaceutics, Pharmaceutical Analysis, Medicinal Chemistry, Pharmacology.

Research Fellow at Department of Radology, University of Michigan (Ann arbor)

Conducted research on ultrasound-mediated controlled drug delivery for angiogenesis in preclinical models of impaired wound healing.

Research Fellow at Engineering and Radiation Oncology, Loyola University Chicago

Conducted research on ultrasound-mediated intrathecal drug delivery for the treatment of brain metastatic cancer.
Designed stereotaxic devices for ultrasound-mediated intrathecal drug delivery in rodent brain cancer models.

Academic Researcher at Centre of Polymer Systems, Tomas Bata University

Engineered self-assembled drug nanoparticles for combinatorial chemo-photodynamic cancer therapy.
Established preparation methods to control particle properties for enhanced tumor targeting.

Focused on engineering biomaterial-based controlled drug delivery systems with direct applications in regenerative medicine, particularly promoting angiogenesis and tissue repair. Expertise lies in utilizing controlled release strategies for therapeutic proteins and small molecules, with a strong specialization in designing and applying ultrasound-responsive materials to achieve precise spatio-temporal control over delivery.

Developed a universal, excipient-free strategy leveraging charge-balanced aggregation for preparing stable aqueous organic nanocrystals from diverse molecules, demonstrating their potential in biomedical applications such as drug delivery.

Xiao H , Li Q. A multi-ring self-dispersing particle system, its preparation method, preparation device, and application. (2023, CN)

Xiao H , A turmeric self-dispersing particle system, preparation therefor and application thereof. (2022, WO)

Xiao H , Li Q. A golden nanpparticle system, preparation therefor and application thereof. (2021, CN)

Xiao H . A self-dispersing particle system, preparation therefor and application thereof. (2021, WO)

Xiao H , Sedlařík V. Preparation and formulation of nanoparticles with enhanced biological availability for use in anticancer therapy. (2018, WO)

Zhao W, He M, Wang Y, Wang Y, He P, Tan X, Fabiilli M, Xiao H* . Self-delivered Aqueous Organic Nanocrystals Enhance Chemo-Immunotherapy via Pyroptosis and Immunogenic Tumour Microenvironment Reprogramming (2025 Under review)

Xiao H , Maji S, Aliabouzar M, Fabiilli M*. Janus Acoustically Responsive Scaffolds for Sequential Drug Release with Phase-Programmed Steady and Pulsatile Kinetics (2025 Under review)

Xiao H , Shrestha B, Cruz AA, Iliff J, Porter T, Aryal M*. The Impact of Anesthesia on Ultrasonic Glymphatic Perturbation Protocol: Alertness, and Glymphatic Influx (2025 Under review)

Zhao W, Li Q, He P, Li C, Aryal M, Fabiilli M, Xiao H* . Charge Balanced Aggregation: A Universal Approach to Aqueous Organic Nanocrystals. (Journal of Controlled Release. 2024 Nov:375:552-573. IF 10.8)

Xiao H , Aliabouzar M, Fabiilli M*. Acoustically Responsive Scaffolds: Unraveling Release Kinetics and Mechanisms for Sustained, Steady Drug Delivery. ( Journal of Controlled Release. 2024 Aug 16:374:205-218, IF 10.8)

Liu H, Yuan M, Liu Y, Guo Y, Xiao H , Guo L, Liu F. Self-Monitoring and Self-Delivery of Self-Assembled Fluorescent Nanoparticles in Cancer Therapy. (Int J Nanomedicine. 2021 Mar 29;16:2487-2499, IF 6.4)

Guo Y, Liu H, Xiao H , Yuan M, Liu Y, Sedlařík V, Chin WC, Liu J, Guo L, Li C. Self-assembled Camptothecin derivatives - Curcuminoids conjugate for combinatorial chemo-photodynamic therapy to enhance anti-tumor efficacy. (J Photochem Photobiol B. 2021 Feb;215:112124, IF 6.252)

Xiao H , Guo Y, Liu H, Liu Y, Wang Y, Li C, Císař J, Škoda D, Kuřitka I, Guo L, Sedlařík V. Structure-based design of charge-conversional drug self-delivery systems for better targeted cancer therapy. (Biomaterials. 2020 Feb;232:119701, IF 12.479)

Xiao H , Sedlařík V. A Rapid and Sensitive HPLC Method for Simultaneous Determination of Irinotecan Hydrochloride and Curcumin in Co-delivered Polymeric Nanoparticles. (J Chromatogr Sci. 2020 Jul 24;58(7):651-660, IF 1.618)

Xiao H* , Wang L. Effects of X-shaped reduction-sensitive amphiphilic block copolymer on drug delivery. (Int J Nanomedicine. 2015 Aug 24;10:5309-25, IF 6.4)

Poster at "24rd Annual International Symposium of International Society for Therapeutic Ultrasound (ISTU)", with topic "Janus Acoustically Responsive Scaffolds for Sequential Drug Release with Phase-Programmed Steady and Pulsatile Kinetics." (Banff, Canada).

Poster at "50th Annual Meeting & Exposition of The Society For Biomaterials (SFB)", with topic "Acoustically responsive scaffolds for sequential drug release with phase-programmed steady and pulsatile kinetics" (Chicago, U.S.).

Poster at "23rd Annual International Symposium of International Society for Therapeutic Ultrasound (ISTU)", with topic "Acoustically Responsive Scaffolds: Unraveling Release Kinetics and Mechanisms for Sustained, Steady Drug Delivery" (Taipei, Taiwan).

Poster at "Biomaterials Day", with topic "Ultrasound influence on fibrin gel degradation and dextrain release: implications for controlled release" (Cleveland, U.S.).

Poster at "Acoustical Society of America", with topic "The efficiency of ultrasonic glymphatic manipulation-based intrathecal drug delivery depends on the physiological states" (Chicago, U.S.).

Invited Oral Presentation at "Bioengineering seminar series", with topic "Drug self-delivery systems for cancer therapy" (California, U.S.).

Oral Presentation at conference "Poly-Char World Forum on Advanced Materials", with topic "A drug self-delivery system for cancer therapy" (Naples, Italy).

Oral Presentation at conference "NewGen Conference: Hydrogel/Bio-mineralised Biomaterial", with topic "Polymeric micellar nano systems for drug delivery" (Zlin, Czech Republic)

Academic Visitor at Qingdao Agricultural University, China. "A drug self-delivery system for myocardial ischemia protection on nude mice".

Academic Visitor at University of California, Merced. "A drug self-delivery system for cancer treatment based on photodynamic therapy".

"HR Mobility" – Research experience in Chengdu University of TCM, China. In vivo therapeutic effects of anti-cancer drugs on nude mice.

Regenerative Medicine Translational Research Fellowship Program, 2025.

Funded by Internal Grant Agency. IGA/CPS/2017/005; IGA/CPS/2018/003; IGA/CPS/2019/006; IGA/CPS/2020/002.

Funded by Ministry of Education, Youth and Sports of the Czech Republic

Design and development of advanced drug delivery systems for multiple applicaitons.

Pharmaceutical Preparation and Characterisation

in vitro and in vivo Evaluation (Biosafety, Delivery efficiency and Drug efficacy) on Rats and Mice.

R programming for data analysis.

Specialized equipment design (Design of stereotaxic devices for rodents)

English (Professional working proficiency)